Last night I've spent few hours trying the newest version of Seesmic Desktop and Tweetdeck, but I still don't think that both of them could actually replace my actual configuration (Twhirl & Facebook Air). I really could have switched to Tweetdeck, the interface is clean and efficient, a lot of options (even though I mostly don't use any) but the main grievance I have with it is that it only supports Facebook Status (nothing about videos or links) without possibilities to "Like" or "Comment", Eliminatory to me.

I know Seesmic Desktop as it's still a pre-version (new word to say "Bêta" ?) but I still have some big problems with the user interface (because the whole idea is quite good actually) which is fixed (the main (blue) column is too narrow and globally not as "clean" (don't know other way to express it) as Tweetdeck's. But once again I won't remain in this position very long, I'll keep trying the newest version as soon as they came out, I know that a lot of improvement are scheduled for both softwares and I'm still really excited about that :)